2. Signaling Pathways
  3. PROTAC
  4. Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

Related Products

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Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.

The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

Target Protein Ligand-Linker Conjugates Related Products (33):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-163019
    EN884 2189497-60-5
    EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs).
    EN884
  • HY-168682
    Adamantane-Butyl alcohol 31685-38-8
    Adamantane-Butyl alcohol is a selective and persistent degrader targeting the CDK8-cyclin C complex. Adamantane-Butyl alcohol is the linker for LL-K8-22 (PROTAC CDK8-cyclin C, HY-149209) and HyT.
    Adamantane-Butyl alcohol
  • HY-132943A
    BRD4 ligand-Linker Conjugate 1 TFA 98.66%
    BRD4 ligand-Linker Conjugate 1 TFA (compound 106-1) is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs.
    BRD4 ligand-Linker Conjugate 1 TFA
  • HY-147050A
    Ahx-DM1 TFA 1702356-22-6
    Ahx-DM1 (TFA) (compound 2A) is a conjugate of protein/peptide which can be combined with a therapeutic, diagnostic or labelling agent.
    Ahx-DM1 TFA
  • HY-132943
    BRD4 ligand-Linker Conjugate 1 2154358-89-9
    BRD4 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used in the synthesis of PROTACs.
    BRD4 ligand-Linker Conjugate 1
  • HY-139403
    MRTX849 ethoxypropanoic acid 2561529-98-2
    MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM).
    MRTX849 ethoxypropanoic acid
  • HY-169488
    SMARCA2 ligand-12-3-methylazetidine
    SMARCA2 ligand-12-3-methylazetidin is a target protein ligand-linker conjugate that incorporates a ligand for SMARCA2 (HY-169487), and a PROTAC linker (HY-W052601), which recruit E3 ligases. SMARCA2 ligand-12-3-methylazetidin can be used to synthesize PROTAC SMARCA2 degrader-25 (HY-169276).
    SMARCA2 ligand-12-3-methylazetidine
  • HY-153424
    PROTAC SMARCA2 degrader-1 2892523-73-6
    PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate.
    PROTAC SMARCA2 degrader-1
  • HY-170769
    FLT3 Ligand-Linker Conjugate 1 2769753-49-1
    FLT3 Ligand-Linker Conjugate 1 (compound 7) contains the FLT3 ligand and a PROTAC linker, which can recruit the E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize the PROTAC RSS0680 (HY-148062). PROTAC RSS0680 is a bifunctional compound that targets protein degradation of kinases.
    FLT3 Ligand-Linker Conjugate 1
  • HY-172126
    JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
    JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a ligand for BRD4, and a PROTACs linker that can be used in the synthesis of PROTAC BRD4 Degrader-29 (HY-172124).
    JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
  • HY-168458
    RNA recruiter-linker 1
    RNA recruiter-linker 1 is the RNA ligand-linker part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNA recruiter-linker 1 can be utilized in the synthesis of RIBOTAC.
    RNA recruiter-linker 1
  • HY-168693
    Target Protein Ligand-Linker Conjugates 2
    Target Protein Ligand-Linker Conjugates 2 is a conjugate of the Target Protein Ligand and Linker, consisting of Desmethyl-QCA276 (HY-44103) and the corresponding Linker. Target Protein Ligand-Linker Conjugates 2 can be used to synthesize PROTAC BD-9136 (HY-149878).
    Target Protein Ligand-Linker Conjugates 2
  • HY-168898
    1,3-Propanediol-SNS-032
    1,3-Propanediol-SNS-032 is a target protein ligand and linker conjugate, which can be used for the synthesis of PROTAC CDK9 autophagic degrader 1 (HY-168896).
    1,3-Propanediol-SNS-032